My New Skincare Protocol [2025]

From: https://blueprint.bryanjohnson.com/blogs/news/my-new-skincare-protocol-2025

Written by Bryan Johnson • 02.25.2025

Hi Friend,

Until I was 40, I kind of destroyed my skin.

Sunburns, poor diet, no skincare routine.
Now I’m paying the price.

Here’s what I’m doing now and what I wish I’d known earlier in life.

When I started Blueprint, my skin was in the 98th percentile for damage on some markers, with an average skin age of 64. Now, my skin age has improved to between 37 and 42.

Here are a few basics to maintain healthy skin:

• Exercise.
• Prioritize your sleep.
• Eat a healthy, Blueprint-like diet.
• Consider getting sun earlier in the day and later in the evenings when the UV index is lower.
• Avoid junk, fried, or highly processed foods, cigarettes, and vaping.
• The sun is good for you but not too much and not too little. Just the right amount will do.
• If you’re getting direct sun exposure when the UV index is high (10 am – 4 pm), you can protect your skin with options such as clothing, a UV umbrella, a hat, and mineral sunscreen.

My daily protocol:

• Face wash morning and night.
• Sunscreen (mineral).
• Moisturize (body and face).
• Targeted Treatments: Use products containing the following active ingredients: 

+ Niacinamide (morning and night) found in serums or moisturizers. 
+ Vitamin C (morning) typically in a serum.
+ Hyaluronic acid (as desired) – usually in a serum or moisturizer.
+ Tretinoin (prescription, at night).

Spot endocrine disruptors in skin care products:
Endocrine disruptors are natural or man-made chemicals that may mimic or interfere with the body’s hormones, known as the endocrine system. These chemicals are linked with many health problems in both wildlife and humans.

Next, here are some supplements to support skin health:

• Collagen (20-30g daily): Pair with Vitamin C to boost collagen synthesisNiacinamide (15 mg in Blueprint Essential Capsules).
• Hyaluronic acid (120 mg in Blueprint Longevity Mix).

Here are some pro tips:

• UV-tinted windows to block 99% of damaging UV rays.
• A UV umbrella during high UV index times.
• Microdosing Accutane (40 mg weekly) for blemish-free skin. Alternatives include over-the-counter retinols.
• Red light therapy 3x per week.

Note: If you don’t have easy access to red light therapy, don’t worry. The basics are a great place to start.

To track my progress, we routinely measure the biological age of my skin using multispectral imaging (in the U.S., Visia is a popular choice).

It provides detailed views of skin health, including:

• UV damage.
• Pore size.
• Dark spots.
• And many other indicators.

Some wellness clinics offer this service. You can search locally to find one.

There a few advanced therapies I’ve been experimenting with to target collagen production, skin firmness, and overall skin health:

• Tixel for improved collagen and elastin.
• Sofwave for improved collagen and elastin.
• Sculptra to boost natural collagen production (injected in the face).

Finally, at Blueprint we are working on some exciting new products to cover all of your skincare requirements. We are developing a cleanser, serum, moisturizer, and SPF that will launch later this year.

I’m excited to be on this journey with you.

Be well,

Bryan

Bryan Johnson’s facial treatments, part of his “Project Blueprint” aimed at reversing aging, combine aggressive, high-tech procedures with a strict daily regimen. Key treatments include Sofwave (ultrasound) and Tixel (thermal energy) for collagen stimulation, Sculptra injections for volume, weekly laser therapy (BBL/Moxi), and daily topical, prescription-strength treatments. Blueprint Bryan Johnson +4

Key Facial Treatments & Technology

• Sofwave & Tixel: Used for non-invasive skin tightening and to stimulate collagen and elastin production without surgery.
• Sculptra Injections: Johnson uses Sculptra to restore facial volume, acting as a “bio-stimulator” that encourages the skin to produce its own collagen rather than using traditional fillers.
• Laser Therapy: He utilizes BBL (BroadBand Light) and Moxi laser treatments to target sun damage, wrinkles, and pore size, aiming for improved skin texture and tone.
• Fat Injections: In 2023, he reported receiving fat injections from a donor to combat volume loss. (BAD)
• Microdosing Accutane: A weekly low-dose regimen of Accutane is used to maintain blemish-free skin.
• Red Light Therapy: Applied three times a week for skin health and mitochondrial healing. Blueprint Bryan Johnson +8

Daily Skincare Routine

• Cleansers & Creams: He uses a consistent routine including Cerave Acne Control Cleanser and a daily sunscreen (SPF 46) to avoid sun damage.
• Actives: His routine includes daily applications of vitamins C, E, and B3 (niacinamide), ferulic acid, azelaic acid, and a 0.1% Tretinoin cream. Blueprint Bryan Johnson +1

His skincare approach, which cost roughly $1600 per month as of March 2026, aims to reverse his skin’s biological age, often using tools like Saluma Pro and red light therapy to track and ensure improvement. 

https://www.hindustantimes.com/lifestyle/health/tech-millionaire-bryan-johnson-face-blows-up-after-scary-botched-procedure-jarring-pics-2-million-per-year-anti-ageing-101731986139769.html